June 15-17,2018
Qingdao, China
Keynote Speakers
》Keynote Speaker


A.Prof./ Vice-dean.Lanhe Zhang(张兰河教授/副院长)
Northeast Electric Power University(东北电力大学)



Title: 
Effect of Na+ and K+ on the performance of denitrifying phosphorus removal and bioflocculation using A2/O process
Abstract: A large amount of wastewater containing Na+ and K+ was generated with the rapid development of industries such as food processing, leather manufacturing and seawater recycling. These ions then entered the urban sewage treatment plants and contacted with the activated sludge, which could affect the pollutant treatment efficiency. The denitrifying phosphorus removal technology can simultaneously remove nitrogen and phosphorus in the sewage, and it has the advantages of saving the carbon source and aeration and reducing sludge emission. In this study, the effect of NaCl and KCl salinity on the removal rates of COD, TN and TP was investigated. The changes of the flocculation and settling properties of activated sludge was studied and the composition and structure of extracellular polymeric substances (EPS) were analyzed by infrared spectroscopy (FTIR) and three-dimensional fluorescence spectroscopy (EEM). The microbial community structure was explored by high-throughput amplification sequencing. The effect of Na+ and K+ on the biological flocculation and microbial community structure of activated sludge was revealed using A2/O denitrifying phosphorus removal process in order to provide a theoretical and practical foundation for the operation and management of the sewage treatment plant.
The results showed that when the influent COD, TN and TP were 670, 80 and 13 mg/L, their removal efficiency were 80%, 72% and 65%, respectively, under the Na+/K+ mole ratio of 2. The release rate of phosphorus in the anaerobic zone was 68%, and the uptake rate in the anoxic and aerobic zones was 52% and 56%, respectively. The SVI and FA in the anaerobic zone were 73 mg/L and 68%, respectively. The SVI and FA in the anoxic zone were 70 mg/L and 68%, respectively. The SVI and FA in the aerobic zone were 75mg/L and 68%, respectively. When the Na+/K+ was 1, the removal efficiency of COD, TN and TP were 84%, 80% and 69%, respectively. Phosphorus release rate in the anaerobic zone was 73%, and the uptake rate in the anoxic and aerobic zones was 55% and 57%, respectively. The SVI and FA in the anaerobic zone were 68 mg/L and 68%, respectively. The SVI and FA in the anoxic zone were 67 mg/L and 68%, respectively. The SVI and FA in the aerobic zone were 66 mg·L-1 and 68%, respectively. When the Na+/K+ was 0.5, the removal efficiency of COD, TN and TP were 86%, 81% and 70%, respectively. Phosphorus release rate in the anaerobic zone was 75%, and the uptake rate in the anoxic and aerobic zones was 56% and 60%, respectively. The SVI and FA in the anaerobic zone were 66 mg/L and 68%, respectively. The SVI and FA in the anoxic zone were 67 mg/L and 68%, respectively. The SVI and FA in the aerobic zone were 63 mg/L and 68%, respectively. The coexist of Na+ and K+ still inhibited the bioflocculation of sludge, and K+ had an inhibitory effect on Na+. When the Na+/K+ is 2 and 1, there existed aromatic proteins, fulvic acids and humic acids in the anoxic and aerobic zones based on the EEM analysis. when Na+/K+ is 0.5, fulvic acids disappearedin the anaerobic zone. with the decrease of Na+/K+, the richness and diversity of microbial communities decreased, the Proteobacteria, Bacteroidetes, Chloroflexi, Firmicutes and Chlorobi were always the dominant phylum in different zone.




A.Prof.Zheng Fan(范峥副教授, 化学工程系副主任)
Xi’an Shiyou University(西安石油大学)


Research Area: Simulation Optimization, Corrosion Control Technology of Oil, Gas Processing

Research Experience:
Zheng Fan works as Associate Professor at College of Chemistry & Chemical Engineering, Xi’an Shiyou University, and serves as Sub-dean of Chemical Engineering Department. He specializes in the area of Simulation Optimization, Corrosion Control Technology of Oil and Gas Processing. He published10 papers by the first author, including 4 EI papers and 5 Chinese core journals. There are 1 publications, which bear 9.7 thousands words. The first inventor has 8 authorized software copyright and 4 authorized invention patents. 1 projects, 1 local and municipal projects, 1 local level projects, 1 local scientific research projects, 1 school grade scientific research projects, 1 scientific research projects at the provincial level, 8 horizontal projects, 4 horizontal projects in the study and 5 teaching and reform projects in participation. 




》Oral Presentation


Senior Eng. Yong Tang(唐勇高级工程师)

Guizhou Panjiang Mining Engineering Technology Center Co., Ltd (贵州盘江采矿工程技术中心有限公司)


Title: Study on utilization of Ventilation Air
Abstract: The total emission of methane in the ventilation air is large, and the concentration is less than 1%. The greenhouse effect of the methane causing is 25 times than carbon dioxide. According to the statistics of the relevant departments, the methane emission from the exhausted air into the atmosphere is equivalent to the gas transmission volume of the west to East Gas Transmission for 1 years, and the greenhouse gas effect is about 2 million tons of carbon dioxide equivalent.Researching and using the problem of  ventilation air is not only protecting the environment, but also a source of energy.
 


Chang Liu(刘畅)
Heilongjiang Bayi Agricultural University(黑龙江八一农垦大学)

Title: Cryptotanshinone induces apoptosis in human gastric cancer cells through ROS-mediated signalling pathway
Abstract: Cryptotanshinone (CT), is extracted from the plant Salvia miltiorrhiza Bunge, has been reported to have potential anticancer effects on human prostate and breast cancer cells. However, the mechanisms of action of CT on gastric cancer (GC) cells are not well understood. In this study, we explored the antitumor activity of CT on GC cells and its possible molecular mechanism. CT inhibited cell viability of 12 kinds of GC cell lines with a dose-dependent manner. CT markedly induced cell cycle arrest at the G2/M phase and mitochondrial apoptosis with the accumulation of reactive oxygen species (ROS). Pretreatment with ROS scavenger N-acetyl-L-cysteine (NAC) could block CT-induced apoptosis. CT could increase the expression levels of p-JNK and p-p38, and decrease the expression levels of p-ERK and p-STAT3, these effects were adverse by NAC. Furthermore, a xenograft assay showed that CT significantly inhibited MKN-45 cell-induced tumor growth in vivo by increasing expression levels of p-JNK, p-38 and cleaved-caspase-3, and reducing expression levels of p-ERK and p-STAT3 without adverse effects on nude mice weight. In general, the present results demonstrated that CT induced apoptosis and cell cycle arrest in GC cells via ROS-mediated MAPK and AKT signaling pathways, and CT may be a potential compound for GC treatment.




Lingqi Meng(孟令旗)

Heilongjiang Bayi Agricultural University(黑龙江八一农垦大学)

Title: Quinalizarin exerts an anti-tumour effect on lung and colorectal cancer cells by modulating ROS-mediated MAPKs and STAT3 signalling pathways
Abstract: 
Quinalizarin (1,2,5,8-tetrahydroxyanthraquinone) may potentially be used as a chemical agent for cancer therapy, because it exerts anti-tumour effects against a variety of cancers. However, the underlying regulatory mechanism and signalling pathways of quinalizarin in lung and colorectal cancer cells remain unknown. The present study sought to investigate the effects of quinalizarin on proliferation, apoptosis and reactive oxygen species (ROS) generation in lung and colorectal cancer. MTT assays were used to evaluate the effects of quinalizarin and 5-fluorouracil on the viability of A549, NCI-H460, NCI-H23, SW480 and HCT-116 cells. Flow cytometry was used to evaluate the effects of quinalizarin on the cell cycle, apoptosis and ROS generation in A549 and SW480 cells. Western blotting was used to detect cell cycle and apoptosis-related protein expression levels of A549 and SW480 cells. Quinalizarin significantly inhibits the viability of A549, NCI-H460, NCI-H23, SW480 and HCT-116 cells in a dose-dependent manner. Quinalizarin induced A549 cell cycle arrest at G0/G1 phase by regulating cyclin D1/E and CDK2/4/6 and induced SW480 cell cycle arrest at G2/M by regulating cyclin B1 and CDK1/2. Quinalizarin induced apoptosis through up-regulating the expression of Bad, cle-caspase-3 and cle-PARP, and down-regulating the expression of Bcl-2 in A549 and SW480 cells. Furthermore, quinalizarin activated mitogen-activated protein kinase (MAPK) and inhibited the Akt and signal transducer and activator of transcription-3 (STAT3) signalling pathways. Additionally, quinalizarin increased ROS generation in A549 and SW480 cells. The ROS scavenger NAC restored quinalizarin-induced cell apoptosis and inactivated the MAPK and STAT3 signalling pathways. The study demonstrated that quinalizarin induces cell cycle arrest and apoptosis via ROS mediated-MAPK and STAT3 signalling pathways in A549 and SW480 cells.



Jiaru Liu(王加茹)
Heilongjiang Bayi Agricultural University(黑龙江八一农垦大学)


Title: 
 The mechanism of novel naphthoquinone derivatives induced apoptosis in human gastric cancer 
Abstract: It is reported that 1,4-naphthoquinones and their derivatives have potent anti-tumor activity in various cancers, although their clinical application is limited by observed side effects. To improve the therapeutic efficacy and to reduce side effects, we synthesized a novel naphthoquinone derivative, 2-(naphthalene-2-thio)-5,8-dimethoxy-1,4-naphthoquinone (NTDMNQ). In this study, we explored the effects of NTDMNQ on apoptosis in gastric cancer cells with a focus on reactive oxygen species (ROS) production. Our results demonstrated that NTDMNQ exhibited the cytotoxic effects on nine gastric cancer cells in a dose-dependent manner. NTDMNQ significantly induced mitochondrial-related apoptosis in AGS cells and increased the accumulation of ROS. However, pre-treatment with N-acetyl-L-cysteine (NAC), an ROS scavenger, inhibited the NTDMNQ-induced apoptosis. In addition, NTDMNQ increased the protein levels of p-JNK, p-p38, Bad, Caspase-3 and PARP, decreasing the levels of p-ERK, p-AKT, p-STAT3 and Bcl-2; these effects were blocked by NAC. Taken together, the present findings indicate that NTDMNQ induced gastric cancer cell apoptosis via ROS-mediated regulation of the MAPK, AKT and STAT3 signaling pathways. Therefore, NTDMNQ may be a potential treatment for gastric cancer as well as other tumor types.
 

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Important Dates
Submission: June 10,2018
Notification: About 2 weeks after the submission
Registration: June 14,2018
Conference: June 15-17,2018
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